4x1 – Folge 1
Alex is back to work where she meets meticulous doctor, Patrick Curtis, with whom she argues. Zach puts his life in danger for the sake of his patient. Charlie takes an important decision regarding his family life.
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4x2 – Folge 2
Charlie is assisted by the prisoner coma patient Crenshaw in dealing with a patient. Maggie tries to decide whether or not to leave Hope Zion and move on with her career. Alex directly questions the judgment of a senior surgeon in the OR.
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4x3 – Folge 3
Patrick and Shahir give a patient contradictory advice about love. Alex is assisted in a surgery by a new resident. Maggie is preparing to leave Hope Zion when she receives an unexpected phone call. Zach has a dispute with a patient that works for the hospital.
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4x4 – Folge 4
Alex's new patient is someone from her past. Zach deals with a female patient that feels responsible for her friend's death. Charlie helps his new ghost cope with her current situation. Charlie finally figures out the truth about Crenshaw.
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4x5 – Folge 5
A motocross rider is diagnosed with Leukemia, forcing Alex to navigate family secrets in order to put her patient on the road to recovery.
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4x6 – Folge 6
Alex must decide whether or not to use information Charlie gets from a patient's spirit in order to save their life.
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4x7 – Folge 7
When an aggressive brain tumor threatens the life of her patient, Alex must convince Shahir to use an equally aggressive treatment.
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4x8 – Folge 8
A dark day for one couple becomes a beacon of hope for others when a rare kidney sets off a transplant chain. The doctors of Hope Zion work to ensure that complications are avoided. In the ward, Dr. Charlie Harris treats the couple but needs the help of Kristine, when the woman's spirit takes to roaming the halls. Meanwhile, Dr. Dana Kinney endures the company of a chatty Poetry Professor, during a chemo session.
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4x9 – Folge 9
When a bomb goes off at a local charity run, Hope Zion Hospital receives the majority of the casualties, including some of its own doctors.
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4x10 – Folge 10
In aftermath of the disaster, Alex struggles with the fact she unknowingly helped the bomber at the expense of a friend.
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4x11 – Folge 11
When an ice storm strikes the city on Christmas Eve, Alex and Dawn struggle to keep a good Samaritan alive long enough for her family to say goodbye.
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4x12 – Folge 12
When a chef with oral cancer refuses care to pursue his life's work, Alex must confront her own feelings about the way Dana is handling her treatment.
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4x13 – Folge 13
Alex must maintain her professionalism when Kristine shows up at Hope Zion Hospital after a drunk-driving accident with baby Luke's blanket.
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4x14 – Folge 14
Alex and Jeremy struggle to find the truth when all the symptoms of a permanently ill child point towards his mother as the cause.
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4x15 – Folge 15
In an attempt to see what his life would be like without his gift, Charlie struggles to heal a superstitious farmer without the help of his spirit Intel.
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4x16 – Folge 16
Alex teams up with Cassie to free a young woman from her abusive partner, while Dawn faces a series of life-threatening complications when a patient's pacemaker malfunctions.
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4x17 – Folge 17
Nurse Kristine suffers a heart attack. Charlie helps her find out why she is not crossing over. A tough surgery affects Maggie's pitch. A misunderstanding develops between Dawn and Zach while romance blossoms between Jeremy and Cassie.
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4x18 – Folge 18
The time has come for Charlie to undergo surgery.
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