When her young daughter is stricken by a mysterious malady, Ichika asks Yasuke to bring them upriver to a special doctor, but Yasuke refuses.

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Back in 1581, Yasuke and Natsumaru have become trusted warriors serving Nobunaga. In the present day, the mercenaries catch up to Yasuke and attack.

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Abraham send Haruto and Nikita to find Saki, who uses her growing powers to fight back. Under torture, Yasuke has a flashback to a betrayal.

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Back in the village, Saki asks Yasuke to bring her to Doctor Marisuke - and she won't take no for an answer. But there are new enemies in pursuit.

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While Morisuke protects Saki from the Daimyo's attack on the Astral Plane, Yasuke confronts the masked Dark General, who reveals their true identity.

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While Morisuke and his men create a protective shield around the temple, Yasuke and Saki face off with the Daimyo in Azuchi Castle.

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