The overnight crew becomes immeresed in a bizarre car-accident rescue, meanwhile Drew serves overseas in Afghanistan and teams with a colleague to treat an Afghani woman; a spunky grad joins the shift.

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TC and Scott work desperately to save a young boy and his mother who were injured in a car accident. With the boy's life hanging in the balance, the team starts to realize there is more to the family dynamic than meets the eye. Meanwhile, Drew and Syd, deployed overseas in Afghanistan, deal with the aftermath of shots fired in the OR.

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Drew returns from deployment in Afghanistan and can't seem to shake off the stress of being back from overseas. Things get crazy right away as he, Jordan and Kenny treat a bride and her wedding party who have been injured during the festivities, as well as her father, whose presence is not making things easier. Meanwhile, TC helps Topher entertain his demanding mother, whose extended visit is putting stress on the family.

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As the city erupts in violence over an impending jury verdict, the night shift becomes ground zero when they have to take in the man suspected of the racially-motivated shooting at the source of the unrest. His presence in the emergency room sparks sharp conversation and disagreements among the staff over the highly-charged topic and even close friends Kenny and Paul find themselves at odds. Topher does his best to control the mounting chaos in the ER while out in the field, TC makes a decision as to which of two patients to bring in, leaving Paul and Scott to ...

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A college co-ed falls from a balcony and once she is in the ER, TC and Paul find that her situation is even more complex. Jordan bonds with a terminal patient who teaches her some important lessons about living. TC's errant sister-in-law Annie returns and hopes to make amends. Meanwhile, Jessica - a pharmaceutical rep with cutting-edge equipment that Scott is so close to getting for the hospital - if her tension with TC doesn't kill the deal.

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Shannon and Jordan venture out for some fun at a local wrestling event only to find themselves treating people on site when a fight breaks out amongst the audience. Back at the hospital, attends to a marathon runner who has collapsed from the heat and things start to heat up even more when the air conditioning breaks. Meanwhile, tensions between TC, Jordan, Sam, and Annie start to boil.

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TC and Topher rush to the scene of a concert where a fireworks explosion has caused massive chaos. As the two jump in to manage the mess, a second explosion causes problems for one of our own. Syd returns from Afghanistan and helps out with the team at San Antonio Memorial but finds herself grappling with best plans for herself and her young daughter. Drew tries to help but runs afoul of their unique family dynamic. Paul and Shannon put aside their differences to treat a patient and find they have more in common than they thought. Meanwhile, Jordan and Scott treat a ...

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Topher's mother arrives in the ER with life-threatening symptoms. As her condition deteriorates, the team works furiously to save her before it's too late. Drew and Shannon treat a gravely injured foster mom and while Drew bonds with the scared young foster daughter, the team discovers the mother has a secret. Meanwhile, Jordan and Scott treat a patient with a rare condition and when an important piece of equipment needed for his treatment fails, Jordan must enlist the help of TC's new girlfriend Jessica whose company makes the machine.

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When a bomb explodes outside the hospital, TC, Topher and Drew are forced to make the tough decision to stay and treat the injured or evacuate and begin transfers to nearby hospitals. Everything changes when TC suddenly realizes he may know the person responsible for the explosion. While the team works feverishly to tend to the wounded, the nurses go on strike just when the hospital needs them the most. Meanwhile, throughout the intense night shift, Shannon and Paul attempt to confront each other about something personal.

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TC risks his life to rescue a victim of a crane collapse and Scott reunites with a boy he paralyzed in the first half of a combined episode.

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Later, TC's hot temper results in a bar brawl and jail time, and Jordan discovers her new date's secret life.

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In part one of this two-part season finale, Scott and Jordan face grave danger during a rescue mission at a rapidly spreading wildfire outside San Antonio. Tensions are high between Syd and TC as they find themselves in the middle of a humanitarian crisis on the Syria-Turkey border. Paul and Shannon argue over treatment for a patient. Meanwhile, a major setback threatens Drew's adoption plans for Brianna, Topher struggles to find a buyer for the hospital and medication goes missing.

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In the second half of this two-part season finale, Scott and Jordan must perform surgery in the field as the burning wildfire gains intensity around them. Syd has caught Typhus along with hundreds of other patients on the Syria-Turkey border, and TC goes to great lengths to get the medication. Meanwhile, Drew and Rick fight to keep Brianna, while San Antonio Memorial finds an unlikely buyer, though saving the hospital comes at a cost.

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