Pivotal moments, whether tragic breaking points or ultimate triumphs, decide the success or failure of individuals struggling with extreme obesity. They must face the reality that weight-loss surgery alone is not the answer to reclaiming their lives.

At over 600 pounds, Brittani's eating has enslaved her and left her marriage without intimacy. She must seek help before her body gives out.

At 700 pounds, Chad's weight is dangerously out of control. After gastric bypass surgery, he quickly sheds pounds but faces a medical crisis when he does not follow the doctor's orders. In dire straits, Chad puts his weight loss journey on the line.

600-pound June copes with the tragic death of her son by eating. After gastric bypass surgery, she must confront the emotional issues driving her food compulsion. If she can stay on track, she can become the mother she desperately wants to be.

Dottie loves being a mom but, at over 600lbs, she's on the verge of leaving her 2 young children motherless. She agrees to a drastic new diet, but her child's life-threatening emergency & her own self-sabotage threaten to derail all hopes for weight-loss.

At 650 pounds, Gideon's weight prohibits him from working, making him completely dependent on his exhausted wife. Desperate for change, he uproots his family to restart his life with weight-loss surgery and hopes for a future of happily-ever-after.

Weighing over 700 pounds at 26 years old, the clock is ticking on Ashley's life. Ashamed of her body, surgery offers hope, but not without setbacks.

At over 700lbs, Teretha's life is confined to a bed which is a far cry from her former job representing Detroit's healthy eating program. Her adoring family fears losing her and hopes a gastric bypass will provide the solution she needs to save her life.

At 650lbs, Randy's food addiction led to the loss of his marriage and visits with his daughter. To regain control of his life, he endures a rigorous pre-surgery diet, surrounded by fast-food temptations. Will he be approved for a weight-loss operation?

At 700lbs, Milla is bedridden and dependent on her husband and five kids. Terrified each day will be her last, they still can't resist her unending requests for junk food. Can Milla stop a lifetime of unhealthy eating to qualify for gastric surgery?

26-year-old Sean weighs over 700-lbs with a massive growth protruding from his side and skin so stretched it is tearing apart. His mother is forced to change both of their lifestyles before he can be approved for gastric bypass surgery.

At 600 pounds, Lupe spent the last 10 years in bed & totally dependent on her husband. A doctor in Texas is her only hope for change. A cross-country move to save her life, may end up backfiring. Did Lupe wait too long to begin her weight-loss journey?

Melissa finds herself overwhelmed with four children, a marriage on the rocks, and an unexpected pregnancy. When Ashley's weight loss journey hits a wall, she sets out to find new inspiration to get herself back on track towards a healthy lifestyle.

Christina's weight loss has gone too far, too fast, and now threatens her life. After losing 300lbs, Paula must endure more surgery to deal with a body entirely covered in loose and sagging excess skin.

Zsalynn is excited for a fresh start but her 360-body lift at a Beverly Hills clinic proves more challenging than expected. Lonely and depressed since her gastric surgery, Olivia wants skin removal surgery but struggles to lose the weight to qualify.

Bettie Jo battles depression and a cancer diagnosis and when she finds out she's pregnant, she and her husband must find a way to cope. Susan suffers a major setback after surgery for her excess skin, thwarting her hopes to conquer her obesity.

Joe has come a long way from being morbidly obese... He's in love and is contemplating proposing to his girlfriend. Charity must find the strength to return to her goals of getting healthy and living a normal life after many post surgery complications.

Despite having lost 378 pounds, Angel's crippling knee pain combined with a legacy of extreme obesity threatens everything she's worked for.

Laura has lost 300lbs+ and is much less dependent on her husband Joey who now he's having trouble finding his way in the relationship. Marla, one of Dr. Now's most challenging patients returns and the fireworks begin all over again.

Pauline must find the will to keep up her weight-loss progress after a medical emergency. Chaye's finally admitting what he's long known, that he's a transgender woman. However, the emotional stress of coming out could threaten his weight loss journey.