Eine Bande skrupelloser Bankräuber entführt nach einem Überfall einen voll besetzten Linienbus. Als der Treibstoff ausgeht, fährt Semir den geforderten Tankwagen. Die Gangster zwingen ihn, den verletzten Busfahrer zu ersetzen.

Der Gangster van Heerlen ist auf der Flucht und bringt Semir in seine Gewalt. Er ahnt nicht, dass er mit einem tödlichen Virus infiziert ist. Tom versucht alles, um seinen Partner zu befreien und den Ausbruch einer Epidemie zu verhindern.

Semir is threatened with being late to a wedding because of the investigation into a bomber case, although he had promised his girlfriend Andrea that he would attend the celebration with her.

During an operation, highway patrolman Bonrath shoots the teenager Marc because he has seen him pointing a gun at his colleague Herzberger. At the same moment he is knocked down from behind.

Highway patrol officers try to solve the death of stewardess Monika Schindler, who apparently panicked and caused a serious accident on the highway.

Jan apparently suffers a fateful mishap: in a highway construction site, he drives too fast and makes a phone call - this causes an accident in which he runs over a man, who is killed instantly. The man was a civil engineer.

Jan and Semir try to solve a failed assassination attempt on the successful rock singer Johnny and protect him from another attack. But their efforts cannot prevent another assassination attempt.

An anonymous bomber blackmails the freight forwarder Giering and blows up one of his tankers. Fortunately, no one is injured. The highway patrol takes over the case. Jan and Semir persuade Giering to go along with the blackmail.

A speeding Porsche 911 Turbo causes a huge pile-up on the Autobahn and drives away. The Porsche, belonging to the chief of medicine of the university hospital, was stolen, after the owner used an online platform to sell his car. The thief, Dennis Weber, gets punished by his superiors in a car smuggling ring for his reckless driving: In order to survive, he uses some photos to blackmail his boss - a big mistake.

Two stoners without a driving license cause a crash on the Autobahn, where several trucks are involved. During the recovery operations, firefighters find a small bag of cocaine, which does not belong to the two stoners, but came from one of the trucks. Jan and Semir are not allowed to investigate, since the truck delivered diplomatic freight for the republic of San Marco, a (fictional) country in South America. However, the cops get suspicious, because all diplomats from San Marco have German names, and do not look south american at all. The first clue leads to a big wine shop in Cologne.

A group of semi-professional thugs fails to carry out a raid on the racetrack's betting office. One staff member gets shot, the thugs are able to escape, and manage to outrun Jan and Semir on the Autobahn by blowing up a tanker truck. Heinrich Lisizki, a senior citizen, who was once an old school criminal, witnessed the unsuccessful attempt at the betting office. Together with his old friend Paul, he decides to carry out his own plan to rob the racetrack, in order to fulfill one of his biggest dreams: Driving to Paris in his old Borgward Isabella. Soon, the two old men are in great danger, because the brutal thugs won't give up that fast.

Semir ends up in hospital after a serious accident with a rental car. When it is discovered that the brake line has been tampered with, Beatrice Gerlach, the manager of the car rental company, admits that she is being blackmailed.

Serious people like Decker do serious business. If their current hacker is caught, he is to be killed right in the police station and another one to be hired. They baldly present themselves as police and promise the most wanted - for conditionally released Raphael Münch it's obtaining tutorship over his daughter. But they don't hesitate to take hostages to threaten too scrupulous workers or to kill their own if those become a burden. Semir and Jan have very scarce hooks but their intuition, Andrea's technical knowledge and recalcitrance of the threatened ones help to save very serious secret state information, while Bonrath and Herzberger sell out indoor plants and organize a Mexican party for the office.

Semir goes undercover on behalf of the LKA to investigate an international car piracy ring run by the so-called "Czar". But Andrea, of all people, blows his cover.

A pushy admirer makes Jan's life hell. At the latest when he is kidnapped, Jan even has to fear for his life. Meanwhile, Semir is desperate to save his colleague from the clutches of the lovesick woman.

A witness in a murder case is put under such massive pressure by the perpetrators that she finally retracts her statement. But this is not enough for the perpetrator: he wants to silence the eyewitness forever.